About Applied StemCell

Applied StemCell (ASC) is a genome engineering platform company advancing the future of genetic and cell-based medicine through its proprietary TARGATT™ and S-SELeCT™ technologies. These innovations enable safe, scalable, site-specific integration of large payloads with reliable gene expression for the development of next-generation therapies, both ex vivo and in vivo.

With deep expertise in induced pluripotent stem cells (iPSCs) and cell line engineering, ASC provides end-to-end solutions that accelerate innovation across academia and biopharma. Our strong IP foundation and cutting-edge technologies empower partners to move from concept to clinic with precision, scalability, and confidence. Please visit www.appliedstemcell.com for more information.

Position Overview

We are currently seeking a highly motivated and experienced Senior Scientist for our R&D group to lead and advance our integrase/recombinase-based genome engineering platform, S-SELeCT. This individual will be responsible for driving the scientific strategy, execution, and delivery of key milestones to establish the technology across multiple use cases and translate it into therapeutic applications. The role requires both deep technical expertise and strong leadership to guide a high-performing research team.

Key Responsibilities / Tasks

· Lead the R&D organization in the development and optimization of S-SELeCT, an integrase/recombinase-based gene insertion platform.

· Define and execute a milestone-driven R&D roadmap aligned with company and board-level strategic objectives.

· Translate platform capabilities into practical applications, including therapeutic development and cell engineering use cases.

· Oversee and perform experimental design, data analysis, and interpretation to ensure scientific rigor and reproducibility.

· Supervise and mentor a team of research scientists and associates, fostering a collaborative and high-performance culture.

· Drive innovation in recombinase engineering, directed evolution, and genome editing technologies.

· Collaborate cross-functionally with commercial, operation, and external partners to support product development and commercialization.

· Ensure timely communication of progress, challenges, and opportunities to executive leadership.

Team Leadership & Influence

Serve as a subject-matter expert and internal product champion.
Mentor junior team members as the organization grows.
Communicate priorities, timelines, and risks to cross-functional stakeholders.

Qualifications

Ph.D. in Molecular Biology, Genetics, Bioengineering, or a related field.
Extensive experience in recombinase/integrase systems and gene editing technologies.
Strong background in directed evolution and cell engineering.
Hands-on experience with iPSC culture and genetic manipulation.
Demonstrated track record of leading R&D teams and delivering complex scientific programs.
Experience translating early-stage technologies into therapeutic or commercial applications is highly preferred.
Experience with gene editing on-/off-target analysis, NGS, library screening, ddPCR and large-scale data analysis

Skills & Competencies

Strategic thinker with the ability to execute in a fast-paced, milestone-driven environment.
Strong leadership and team management skills; able to inspire, mentor, and develop talent.
Excellent problem-solving and decision-making capabilities.
Effective communicator, capable of presenting complex scientific concepts to diverse audiences.
Collaborative mindset with a willingness to work cross-functionally.
Strong ability to translate complex scientific concepts into clear messaging.
Excellent written and verbal communication skills.
Highly organized, proactive, and comfortable in a fast-paced environment

Reports to: Head of Research & Development

Job Type: Full-time

Pay: From $140,000.00 per year

Benefits:

401(k)
Dental insurance
Employee assistance program
Flexible spending account
Health insurance
Health savings account
Paid time off
Relocation assistance
Vision insurance

Work Location: In person

Applied StemCell, Inc.

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