Job Introduction

Thanks for checking out our vacancy, we’re delighted you want to learn more about Dechra!

Dechra is a growing, global specialist within the world of veterinary pharmaceuticals. Our expertise is in the development, manufacture, marketing and sales of high quality products exclusively for veterinarians worldwide.

Here at Dechra, our values are embedded within our culture and thrive within our family of almost 3000 colleagues globally. From manufacturing to marketing, (D)edication, (E)njoyment, (C)ourage, (H)onesty, (R)elationships and (A)mbition are at the heart of our everyday operations and the way we do business.

The Opportunity

Provide Bioinformatics expertise to advance antibody discovery efforts for companion animals (dogs, cats, horses).

Main Responsibilities

So, what will you be doing? This role has a broad and varied scope and the successful candidate will have responsibility for duties including:

Provide new target analysis by accessing and analyzing genomic and RNA-Seq datasets in the public domain.
Oversee external efforts to verify sequences for cat, dog or horse genes not currently in the publicly available databases
Oversee development of user-friendly databases containing antibody repertoire sequences from dog, cat and horse.
Lead the design of streamlining the input of data into Benchling to continuously improve data entry and organisation.
Carry out sequence liability remediation, and other biophysical property improvement of antibodies utilizing rational in-silico design approaches and/or publicly available software.
Assist in overseeing external collaborations utilising machine learning approaches
Curation and integration of relevant dog, cat, and horse genomic and RNA-Seq datasets from the public domain.
Analyse large numbers of antibodies from discovery campaigns by using clustering methods (clonotyping, sequence-based…)

The Ideal Candidate

Here at Dechra we pride ourselves on being an inclusive employer and we embrace candidates from all walks of life. We’re particularly excited to hear from those who have/are:

In-depth knowledge and experience working with therapeutic antibodies (human or dog/cat) is required.
Knowledge of machine learning approaches for protein design & biological data analysis.
Proficient in antibody engineering, including experience with antibody sequence liability remediation and biophysical property improvement.
Experience with next generation sequencing data analysis (DNA & RNA)

Desirable

Experience with successful implementation of bioinformatics tools for scientific data management and analysis of large datasets such as machine learning or other state-of-the-art approaches (e.g. from next generation sequencing applications and antibody library sequencing) and harmonizing different types of data sets for analyses.
Familiarity with molecular modeling softwares such as Rosetta, Schrodinger, Molecular Operating Environment (MOE)
Experience with next generation sequencing data analysis (DNA & RNA)

About The Company

As a people first values-based culture, we provide free weekly wellness sessions focused on our employee's physical and mental wellbeing, and flexible work arrangements. We offer a generous employer 401k match and an other incentives for long-term financial wellness. Our full array of health, financial and voluntary benefit programs are what you would expect from a recognized Best Place to Work.

Dechra Pharmaceuticals PLC

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