The Zimmerman lab at OUHSC is broadly focused on understanding the function of monocytes and tissue resident macrophages in mouse models of polycystic kidney disease (PKD), acute kidney injury (AKI), and heart failure with preserved ejection fraction (HFpEF) using stateoftheart techniques including single cell RNA sequencing (scRNAseq) and spatial transcriptomics. Using omics’ approaches, we have defined how disease sequalae alters macrophage phenotype in mouse models and developed monocyte/macrophage specific knockout mice to test the functional importance of predicted cytokines in vivo. We have also set our sights on understanding how omics data from human patients crossreferences across model systems including mice, rat, and organoids using deep learning approaches.

Responsible for providing bioinformatics support for research projects, constructing and maintaining databases, and writing programs. Assists researchers by collecting data, keeping records, conducting literature and technical research, analyzing data, preparing reports, and working with other bioinformatics support personnel. Assists with experimental design and interpretation of results.

Duties:

Analyzes sequencing and proteomic data by importing, examining, and running statistical analyses and modeling algorithms. Analyzes data from a variety of experiments and platforms. Interprets, draws conclusions, and discusses results with principal investigator.
Develops and maintains relational databases for high throughput data archiving and analysis. Assists with data deposition to public databases.
Provides user training and assistance to researchers for various bioinformatics software analysis packages and users who wish to incorporate this expertise into their own laboratory. Responds to end
user problems and requests relating to genome/proteome data.
Installs software packages related to bioinformatics.
Continues to stay abreast of changing technologies, programming language developments, and new product items to support and enhance job performance.
Performs various duties as needed to successfully fulfill the function of the position.

Job Requirements

Required Education: Bachelor's degree in a relevant field (e.g., Biology, Neuroscience, Biochemistry, or Microbiology with a computational focus; Computer Science with a biological focus; or a related discipline)

Skills:

Knowledge of cell, molecular biology, and bioinformatics including but not limited to genome sequencing and protein analysis, and analysis of Next Generation Sequencing data (e.g., RNAseq, ChIP

seq, exome sequencing).
Knowledge of Unix, Linux, and Windows operating systems.
Knowledge of MySQL databases and scripting languages such as Python, PHP, Java and Perl.
Knowledge of genomic and/or proteomic data analyses, computer programming, database design and maintenance.
Working knowledge of statistical analysis in a research environment
Ability to communicate verbally and in writing.
Ability to work independently and as a team member.

Certifications: None

Advertised Physical Requirements:

Physical:
- Sitting for prolonged periods.
- Manual Dexterity.
- Speaking, listening, reaching and bending.
Environmental:
- Standard Office Environment.

Departmental Preferences: None

Why You Belong at the University of Oklahoma: The University of Oklahoma values our community's unique talents, perspectives, and experiences. At OU, we aspire to harness our innovation, creativity, and collaboration for the advancement of people everywhere. You Belong Here!

Equal Employment Opportunity Statement: The University, in compliance with all applicable federal and state laws and regulations, does not discriminate on the basis of race, color, national origin, sex, sexual orientation, marital status, genetic information, gender identity/expression (consistent with applicable law), age (40 or older), religion, disability, political beliefs, or status as a veteran in any of its policies, practices, or procedures. This includes but is not limited to admissions, employment, housing, financial aid, and educational services.

Hiring contingent upon a Background Check?: Yes

Special Indications: None

Job Posting: Dec 12, 2025

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Bioinformatics Analyst