Ready to redefine what's possible in molecular diagnostics?

Join a team of brilliant, passionate innovators who wake up every day determined to transform healthcare. At BillionToOne, we've built something extraordinary—a culture where transparency fuels trust, collaboration drives breakthroughs, and every voice matters in our mission to make life-changing diagnostics accessible to all. We don't just aim for incremental improvements; we strive to build products that are 10x better than anything that exists today. Our people are our greatest asset:talented scientists, engineers, sales professionals, and visionaries united by an unwavering commitment to changing the standard of care in prenatal and cancer diagnostics. This is where cutting-edge science meets human compassion—every innovation you contribute helps remove fear of unknown from some of life's most critical medical moments. If you're driven by purpose, energized by innovation, and ready to help build the future of precision medicine, this is where you belong.

The Prenatal Reporting Clinical Laboratory Scientist (RCLS) is responsible for performing high complexity laboratory analysis on patient specimens, performing quality control and quality assurance procedures, and complying with all local, state, and federal laboratory requirements. The RCLS will be involved with training and troubleshooting and may assist the Supervisor with scheduling, meeting project deliverables and the general supervision of personnel and the daily operations of the laboratory as applicable. The RCLS may be the first point of contact for other cross-functional teams during specimen processing and will provide guidance while troubleshooting technical and non-technical problems as applicable.

The nature of the work performed by a RCLS requires excellent attention to detail, strong written and verbal communication skills, the ability to multitask and be flexible with scheduling, and the ability to work both independently and in a team environment.

Responsibilities:

Clinical Data Review, Interpretation, and Reporting:
- Review and interpret clinical genomics data, and sign out clinical laboratory reports, ensuring accuracy and reliability of clinical reporting
Quality Assurance:
- Partner with Quality Management team on QC and QA programs to maintain the highest standards in laboratory testing and reporting, ensuring adherence to CLIA, CAP, and other regulatory guidelines
Process Improvement:
- Identify opportunities for process optimization, efficiency enhancement, and cost-effective laboratory practices
- Collaborate with Research & Development, bioinformatics and Genomic Technology team to develop, validate, and implement of new laboratory tests, methodologies, and data management and reporting systems
Team Leadership:
- Provide leadership and guidance to laboratory staff, including scientists, technicians, and support personnel
Collaboration:
- Collaborate with cross-functional teams, including Lab Operation, Customer Service, Product, Commercial, to support company goals
Analysis and Reporting (70%):
- Execute the bioinformatics pipelines that process and analyze raw data from samples
- Manage daily test processing needs with the highest emphasis on quality
- Present sample results to additional RCLSs, Laboratory Director, and/or other clinical personnel for subsequent clinical reporting
- Reviewing and releasing sample reports under the purview of the Laboratory Director
Other Responsibilities (30%):
- Maintain reporting workflows, documentation, and their compatibility with laboratory workflows
- Assist with technology transfer from the research laboratory to the clinical laboratory
- Assist with continual process & workflow improvement on existing productions across teams
- Close collaboration with additional clinical teams: Client Services, Genetic Counselors, Bioinformatics, and Process Engineering for investigation on samples and/or workflows
- Train other Reporting CLS and clinical personnel on bioinformatics and reporting pipelines as needed
- Weekend and holiday work may be required
- 60% on-site expected (3 days/week onsite, 2 days/week remote)

Qualifications:

Must possess an active and valid CLS or Clinical Genetic Molecular Biologist Scientist (CGMBS) license issued by the state of California pursuant to Division 2, Chapter 3 of the California Business and Professions Code or to practice medicine, osteopathy or podiatry pursuant to Division 2, Chapter 5 of the California Business and Professions Code appropriate to the specialty they are performing
- Must fulfill requirements stated in 42 CFR 493.1489 OR 493.1491
- Must fulfill requirements stated in the College of American Pathologists Molecular Pathology Checklist
- Working knowledge of local, state, and federal laboratory regulations required
Bachelor's degree or equivalent in Biomedical Laboratory Sciences, Clinical Science or related field required
At least one year of Clinical Laboratory experience or equivalent high complexity and volume laboratory experience required
Experience with molecular biology techniques required
Experience with Sanger sequencing analysis, trinucleotide repeat analysis, MLPA analysis, or NGS QC preferred
Laboratory experience in molecular biology within the last year preferred
Strong computer and automation skills are preferred
- Knowledge of data structures and algorithms and familiarity with industry tools (Atlassian Suite, Microsoft Office Suite, LIMS, command line)
Able to manage daily test processing needs with high emphasis on quality
Able to analyze and troubleshoot basic issues that impact test performance
Able to integrate and apply feedback in a professional manner
Able to proactively communicate consistently, clearly, and honestly

Benefits And Perks:

Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients
Open, transparent culture that includes weekly Town Hall meetings
The ability to indirectly or directly change the lives of hundreds of thousands patients
Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered up to 80%
Extremely generous Family Bonding Leave for new parents (16 weeks, paid at 100%)
Supplemental fertility benefits coverage
Retirement savings program including a 4% Company match
Increase paid time off with increased tenure
Latest and greatest hardware (laptop, lab equipment, facilities)
Free daily on-site lunches provided from top eateries
A variety of perks on campus (state of the art gym, restaurant)
Free on-site EV charging (compatible with all EVs, including Tesla)

At BillionToOne, we are proud to offer a combination of a (1) base pay range (actual amount offered is based on experience and salary/equity options split that the candidate chooses), (2) generous equity options offering, (3) corporate bonus program, on top of (4) industry leading company benefits (free healthcare options, 401k match, very generous fully paid parental leave, etc.).

For this position, we offer a total compensation package of up to $172,625 per year, including a base pay range of $126,721 - $147,841 per year.

BillionToOne is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

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About BillionToOne

BillionToOne is a next-generation molecular diagnostics company on a mission to make powerful, accurate diagnostic tests accessible to everyone. Our revolutionary QCT molecular counting technology enhances disease detection resolution by over a thousandfold using cell-free DNA—a breakthrough that's already transformed the lives of over half a million patients worldwide.

Our Impact: We've pioneered game-changing diagnostic solutions that are redefining industry standards. Unity Complete™ stands as the only non-invasive prenatal screen capable of assessing fetal risk for both common recessive conditions and aneuploidies from a single maternal blood sample. In oncology, our Northstar® liquid biopsy test uniquely combines treatment selection with real-time monitoring, giving oncologists unprecedented precision in cancer care.

Our Growth: From $0 to $125 million in Annual Recurring Revenue in just four years. We've raised close to $400 million in funding, including a $130 million Series D round in June 2024, achieving a valuation of over $1 billion. This backing comes from world-class investors including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest.

Our Recognition: Forbes recently named us one of America's Best Startup Employers for 2025, and we were awarded Great Place to Work certification in 2024—with an incredible 100% of our people reporting they are willing to give extra to get the job done. These honors recognize not just our innovation but the exceptional culture we've cultivated—one that remains authentically collaborative and transparent even as we've scaled.

Our Future: Headquartered in Menlo Park with facilities in Union City, California, we're continuing to push the boundaries of what's possible in molecular diagnostics. Recent clinical outcomes data for Unity Fetal Risk Screen and new advances in cancer diagnostics prove we're just getting started.

At BillionToOne, you'll join a diverse team of passionate innovators who believe that the best science happens when brilliant minds collaborate openly, think boldly, and never lose sight of the patients whose lives depend on our work.

Ready to help us change the world, one diagnosis at a time?

Learn more at www.billiontoone.com

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